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Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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A Single-Blinded Prospective Study on Using Botulinum Toxin Type A for Reducing Alar Mobility.

Yehong Zhong1, Dejun Cao1, Sizheng Zhou1

  • 1Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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Summary

Botulinum toxin effectively reduces alar mobility and improves dynamic nasal aesthetics. This minimally invasive treatment offers a new option for patients seeking cosmetic enhancement or supplemental rhinoplasty procedures.

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Area of Science:

  • Plastic Surgery
  • Dermatology
  • Aesthetic Medicine

Background:

  • Growing demand for minimally invasive cosmetic procedures to enhance facial aesthetics.
  • Limited practical treatments available for reducing dynamic nasal alar mobility.

Purpose of the Study:

  • To evaluate the efficacy of botulinum toxin type A in reducing nasal alar mobility.
  • To assess botulinum toxin as a supplemental treatment option for rhinoplasty.

Main Methods:

  • A single-blind prospective study involving 20 participants.
  • Injection of 3U botulinum toxin type A into specific nasal muscles in the experimental group.
  • Measurement of alar mobility using a 3D imaging system before and after treatment, comparing to a saline control group.

Main Results:

  • Significant reduction in alar flaring and base mobility in the botulinum toxin group (P < 0.05).
  • No significant changes in alar mobility observed in the control group.
  • Root mean square analysis indicated significantly greater changes in the experimental group compared to the control (P < 0.05).

Conclusions:

  • Botulinum toxin type A is effective in reducing alar mobility.
  • The treatment offers a safe, minimally invasive option for improving dynamic alar aesthetics.
  • Botulinum toxin can be a valuable supplemental treatment in rhinoplasty procedures.