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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Related Experiment Video

Updated: Oct 19, 2025

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Foot Reflexology: An Intervention for Pain and Nausea Among Inpatients With Cancer.

Kristen D Anderson1, Marty Downey2

  • 1St. Luke's Cancer Institute.

Clinical Journal of Oncology Nursing
|September 17, 2021
PubMed
Summary

Foot reflexology significantly reduced pain in cancer patients compared to standard care. While nausea reduction was not statistically significant, it showed clinical relevance, suggesting potential benefits for symptom management in oncology.

Keywords:
integrative therapiesnauseapainreflexologyside effectssymptom management

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Area of Science:

  • Oncology
  • Complementary Therapies
  • Symptom Management

Background:

  • Pain and nausea are common symptoms for cancer patients.
  • Foot reflexology has shown potential benefits in managing these symptoms.
  • Further research is needed to confirm efficacy.

Purpose of the Study:

  • Evaluate the effects of foot reflexology on pain and nausea in cancer inpatients.
  • Compare foot reflexology to traditional nursing care.
  • Conduct a randomized controlled trial.

Main Methods:

  • Pilot study on a 24-bed inpatient oncology unit.
  • 40 adult cancer patients randomized into intervention (foot reflexology) and control groups.
  • 20-25 minute sessions with pre- and post-session surveys.

Main Results:

  • Foot reflexology significantly decreased pain compared to traditional care.
  • Nausea reduction was not statistically significant but showed clinical relevance.
  • Intervention group reported decreased nausea ratings post-session.

Conclusions:

  • Foot reflexology is effective in reducing pain for cancer inpatients.
  • Foot reflexology may offer clinical benefits for nausea management.
  • Further investigation into reflexology for cancer symptom control is warranted.