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Related Experiment Video

Updated: Oct 19, 2025

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

Closed incision Negative Pressure Therapy (ciNPT): does depression affect underlying tissues?

D Gui¹, A Casaroli, A Borrello

¹Department of Emergency and Trauma Surgery, Policlinico Gemelli, Catholic University of Sacred Heart, Rome, Italy. alebor93@gmail.com.

European Review for Medical and Pharmacological Sciences

|September 17, 2021

Summary

This summary is machine-generated.

Closed incision Negative Pressure Therapy (ciNPT) does not transmit negative pressure to underlying tissues. Potential benefits of ciNPT may stem from mechanisms other than pressure diffusion within surgical wounds.

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Area of Science:

Biomedical Engineering
Surgical Innovation
Wound Healing Research

Background:

Closed incision Negative Pressure Therapy (ciNPT) is increasingly used for surgical wounds.
Its proposed benefit involves negative pressure spreading within the wound to remove fluid and edema.
Empirical evidence supporting this mechanism is limited in existing literature.

Purpose of the Study:

To investigate the transmission of negative pressure within closed surgical incisions.
To determine if ciNPT effectively distributes sub-atmospheric pressure to deeper wound tissues.
To provide experimental data on the biomechanics of ciNPT in sutured wounds.

Main Methods:

Experimental study utilizing a porcine model with newly sacrificed animals.
Measurement of pressure at the base of three surgically created abdominal wounds.
Application of commercial negative pressure therapy sets to sutured wounds for several hours.

Main Results:

Negative pressure applied to the surface of sutured wounds did not transmit to the underlying tissues.
A deep-layer deposited blue dye did not migrate to the surface, indicating a lack of fluid displacement via pressure diffusion.
ciNPT did not demonstrate pressure transmission into the wound planes or deeper tissues.

Conclusions:

The findings challenge the assumption that negative pressure diffuses effectively within closed incisions.
The benefits of ciNPT on sutured wounds likely arise from alternative mechanisms.
Further research is needed to elucidate the precise mechanisms of action for ciNPT.