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Related Concept Videos

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Related Experiment Video

Updated: Oct 19, 2025

High-Throughput Total Internal Reflection Fluorescence and Direct Stochastic Optical Reconstruction Microscopy Using a Photonic Chip
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Millimeter-scale chip-based supercontinuum generation for optical coherence tomography.

Xingchen Ji1, Diana Mojahed1,2, Yoshitomo Okawachi3

  • 1Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

Science Advances
|September 17, 2021
PubMed
Summary
This summary is machine-generated.

We developed a compact silicon nitride photonic chip for supercontinuum generation, enhancing optical coherence tomography (OCT) imaging. This platform offers high sensitivity and depth performance for portable OCT applications.

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Area of Science:

  • Photonics
  • Biomedical Imaging
  • Materials Science

Background:

  • Supercontinuum sources are crucial for optical coherence tomography (OCT), offering broad bandwidth for high resolution and high power for improved sensitivity.
  • Current fiber-based supercontinuum systems necessitate high pump powers, optical filters, and exhibit limitations in sensitivity and depth performance.

Purpose of the Study:

  • To introduce a novel supercontinuum generation platform using a silicon nitride (Si3N4) photonic chip for OCT.
  • To demonstrate efficient supercontinuum generation near 1300 nm without postfiltering.
  • To evaluate the performance of this platform in a spectral domain OCT system.

Main Methods:

  • Fabrication of a 1-mm² Si3N4 photonic chip.
  • Direct pumping of the chip to generate supercontinuum near 1300 nm.
  • Integration of the chip into a spectral domain OCT system.
  • Characterization of spectral bandwidth, system sensitivity, and depth performance.

Main Results:

  • Efficient supercontinuum generation with a 105 nm flat 3-dB bandwidth was achieved using a 25-pJ pump pulse.
  • The integrated OCT system demonstrated 105-dB sensitivity and 1.81-mm 6-dB sensitivity roll-off at 300-μW optical power.
  • Successful imaging of breast tissue confirmed the platform's strong performance.

Conclusions:

  • The Si3N4 photonic chip enables efficient, filter-free supercontinuum generation for OCT.
  • This platform significantly enhances OCT sensitivity and depth performance.
  • The developed chip holds promise for portable OCT systems and the integration of photonics in optical imaging.