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Related Concept Videos

Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

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Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
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Long-term Potentiation01:25

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Propagation of Action Potentials01:23

Propagation of Action Potentials

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The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
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Graded Potential01:19

Graded Potential

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Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
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Action Potentials01:41

Action Potentials

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Overview
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Integration of Synaptic Events01:28

Integration of Synaptic Events

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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
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Updated: Oct 19, 2025

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
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Rectified Linear Postsynaptic Potential Function for Backpropagation in Deep Spiking Neural Networks.

Malu Zhang, Jiadong Wang, Jibin Wu

    IEEE Transactions on Neural Networks and Learning Systems
    |September 17, 2021
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    Summary
    This summary is machine-generated.

    Spiking neural networks (SNNs) achieve state-of-the-art accuracy using a novel spike-timing-dependent backpropagation (STDBP) algorithm. This method enables ultralow-power, event-driven inference on neuromorphic hardware.

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    Area of Science:

    • Neuromorphic computing
    • Artificial intelligence
    • Computational neuroscience

    Background:

    • Spiking neural networks (SNNs) mimic biological neurons for efficient, event-driven processing.
    • Training deep SNNs (DeepSNNs) is challenging as standard backpropagation (BP) is not directly applicable.
    • Temporal coding in SNNs uses spike timing for information representation.

    Purpose of the Study:

    • To investigate the limitations of error BP in DeepSNNs.
    • To propose a novel learning algorithm for DeepSNNs that utilizes spike timing.
    • To demonstrate ultralow-power inference using DeepSNNs on neuromorphic hardware.

    Main Methods:

    • Developed a rectified linear postsynaptic potential (ReL-PSP) function for spiking neurons.
    • Introduced a spike-timing-dependent BP (STDBP) learning algorithm for event-driven training.
    • Implemented and evaluated DeepSNNs on a neuromorphic inference accelerator.

    Main Results:

    • DeepSNNs trained with STDBP achieved state-of-the-art classification accuracy on the MNIST dataset.
    • Neuromorphic hardware demonstrated ultralow power consumption (0.751 mW) and low latency (47.71 ms).
    • Spike timing dynamics were shown to be crucial for information encoding, synaptic plasticity, and decision-making.

    Conclusions:

    • The proposed STDBP algorithm effectively trains DeepSNNs, enabling high accuracy and efficient inference.
    • Spike timing is a key factor for advancing SNNs and neuromorphic hardware design.
    • This research offers a new perspective for developing future DeepSNNs and neuromorphic systems.