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Histological Findings After Aortic Cross-Clamping in Preclinical Animal Models
Hamdy Awad1, Alexander Efanov1, Jayanth Rajan1
1From the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Journal of Neuropathology and Experimental Neurology
|September 17, 2021
Summary
Spinal cord injury after aortic aneurysm repair predominantly affects grey matter. This review examines histological findings in preclinical models over 40 years, highlighting grey and white matter damage.
Area of Science:
- Neurology
- Vascular Surgery
- Histopathology
Background:
- Spinal cord ischemic injury and paralysis are severe complications following open surgical repair of thoracoabdominal aortic aneurysms.
- Preclinical models are crucial for understanding the neuropathophysiology and developing treatments for these injuries.
Purpose of the Study:
- To systematically review and analyze histological findings in preclinical models of spinal cord injury after open surgical repair of thoracoabdominal aortic aneurysms over the past 40 years.
Main Methods:
- Systematic literature review of preclinical studies.
- Analysis of histological findings in spinal cord tissue from animal models.
- Focus on studies published within the last 40 years.
Main Results:
- Histological examination revealed predominant damage in the grey matter of the spinal cord.
- White matter damage in the spinal cord was also observed in preclinical models.
- The review synthesized neuropathological findings from diverse preclinical studies.
Conclusions:
- Grey matter is the primary site of spinal cord damage following open surgical repair of thoracoabdominal aortic aneurysms in preclinical models.
- Further research is needed to investigate neuropathological outcomes in preclinical models after endovascular repair.
