Break Away: FKBP12 sequestration as a target for increasing BMP activity
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Martha C Taubert1, Felix Hausch1
1Department of Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287 Darmstadt, Germany.
Cell Chemical Biology
|September 17, 2021
Abstract:
Bone morphogenetic protein (BMP) signaling contributes to acute kidney injury (AKI), a common disease without adequate treatment options. In this issue of Cell Chemical Biology, Larraufie, Gao and colleagues (Larraufie et al., 2021) show that FKBP12 inhibition can be a target for treatment of AKI via activation of BMP signaling.

