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The Cardiac Effects of COVID-19: Review of articles

Sana Niazi1, Feizollah Niazi2, Farideh Doroodgar3

  • 1Medical Students Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Current Problems in Cardiology
|September 17, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus (SARS-CoV-2), the cause of COVID-19, significantly impacts cardiovascular health. Understanding COVID-19

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly affected cardiovascular wellbeing.
  • Individuals with pre-existing heart conditions face elevated risks of severe illness and mortality.
  • COVID-19 presents with diverse cardiovascular manifestations, including acute coronary syndromes, myocardial injury, myocarditis, arrhythmias, heart failure, and thromboembolism.

Purpose of the Study:

  • To elucidate the direct and indirect cardiovascular effects of SARS-CoV-2 infection.
  • To examine the potential adverse cardiac effects of COVID-19 therapeutics.
  • To understand the role of the renin-angiotensin-aldosterone system (RAAS) in viral replication and its implications for patients on RAAS-modulating medications.
  • To highlight the necessity of detailed knowledge regarding COVID-19's cardiovascular symptoms and RAAS's prognostic significance for optimal patient management.

Main Methods:

  • Review of clinical data and existing literature on COVID-19 and cardiovascular complications.
  • Analysis of the interaction between SARS-CoV-2 and the renin-angiotensin-aldosterone system.
  • Evaluation of the impact of RAAS-modulating therapies in the context of COVID-19.

Main Results:

  • SARS-CoV-2 infection can precipitate a range of acute cardiovascular syndromes.
  • Pre-existing cardiovascular disease is a significant risk factor for poor COVID-19 outcomes.
  • The interplay between SARS-CoV-2 and the RAAS presents complex challenges for patient care and therapeutic strategies.

Conclusions:

  • Comprehensive understanding of COVID-19's cardiovascular manifestations is crucial for effective clinical management.
  • The role of the RAAS in COVID-19 pathogenesis and prognosis requires further investigation to guide therapeutic decisions.
  • Multidisciplinary approaches are essential to address the complex cardiovascular sequelae of COVID-19.

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