Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoxia01:23

Hypoxia

1.4K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.4K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

384
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
384
Cancer Therapies02:49

Cancer Therapies

8.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.3K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

1.3K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.3K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

445
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
445
Physiological Control of Respiration01:23

Physiological Control of Respiration

4.5K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A five-gene qPCR signature can classify type 2 asthma comparably to microscopy of induced sputum from severe asthma patients.

European clinical respiratory journal·2024
Same author

Targeted next generation sequencing panel for HPV genotyping in cervical cancer.

Experimental and molecular pathology·2020
Same author

Molecular and biological rationale of hyperthermia as radio- and chemosensitizer.

Advanced drug delivery reviews·2020
Same author

Baseline findings of the population-based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65-74 years.

The British journal of surgery·2019
Same author

IMRT - Biomarkers for dose escalation, dose de-escalation and personalized medicine in radiotherapy for head and neck cancer.

Oral oncology·2018
Same author

Methodological development and biological observations of cell free DNA with a simple direct fluorescent assay in colorectal cancer.

Clinica chimica acta; international journal of clinical chemistry·2018

Related Experiment Video

Updated: Oct 19, 2025

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.6K

Therapeutic Modification of Hypoxia.

M R Horsman1, B S Sørensen2, M Busk3

  • 1Experimental Clinical Oncology - Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|September 18, 2021
PubMed
Summary

Tumor hypoxia, or low oxygen, reduces cancer treatment effectiveness and worsens outcomes. Strategies to target tumor hypoxia show promise but are not yet standard clinical practice.

Keywords:
Hypoxiahypoxia imagingradiotherapytherapeutic modifiers

More Related Videos

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
05:45

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

Published on: November 2, 2015

7.4K
Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

85.5K

Related Experiment Videos

Last Updated: Oct 19, 2025

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.6K
Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
05:45

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

Published on: November 2, 2015

7.4K
Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

85.5K

Area of Science:

  • Oncology
  • Radiation Oncology
  • Cancer Biology

Background:

  • Hypoxia (reduced oxygen) is prevalent in solid tumors and linked to treatment resistance.
  • Tumor hypoxia negatively impacts radiotherapy outcomes and promotes malignant progression.
  • Hypoxia contributes to resistance against various cancer therapies, including immunotherapy.

Purpose of the Study:

  • To review the significance of tumor hypoxia in cancer.
  • To discuss clinical imaging techniques for detecting tumor hypoxia.
  • To focus on hypoxia-modifying strategies in clinical evaluation.

Main Methods:

  • Review of preclinical and clinical studies on tumor hypoxia.
  • Analysis of hypoxia imaging modalities.
  • Evaluation of hypoxia-targeting therapeutic strategies.

Main Results:

  • Hypoxia is a significant factor in radioresistance and poor therapeutic outcomes.
  • Various strategies exist to overcome hypoxia, including oxygenation, sensitization, targeted cell killing, and dose modification.
  • Despite clinical trial successes, hypoxia modification is not yet standard care.

Conclusions:

  • Hypoxia remains a critical challenge in cancer therapy.
  • Clinical imaging and targeted interventions are advancing hypoxia management.
  • Further integration of hypoxia-targeting strategies into routine practice is needed to improve patient survival.