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Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy

Juan Mario Solis Paredes1, Otilia Perichart Perera2, Araceli Montoya Estrada3

  • 1Department of Human Genetics and Genomics, Instituto Nacional de Perinatologia, Mexico City, Mexico.

Obesity Facts
|September 18, 2021
PubMed

Insights

Excessive gestational weight gain in pregnancy is linked to altered adipokine levels and increased oxidative stress markers. These changes in adipokines and oxidative stress are associated with abnormal adipose tissue accumulation during pregnancy.

Area of Science:

  • Reproductive biology
  • Metabolic health
  • Biochemistry

Background:

  • Gestational weight gain (GWG) significantly impacts maternal and infant health.
  • Excessive GWG is associated with adverse outcomes like gestational diabetes and future obesity.
  • Adipose tissue dysfunction and oxidative stress are implicated in abnormal GWG.

Purpose of the Study:

  • To investigate the relationship between adipokines and oxidative stress markers in pregnant women.
  • To determine how gestational weight gain influences these associations.

Main Methods:

  • Maternal serum samples were collected in the third trimester (n=74).
  • Assayed adipokines (adiponectin, leptin, resistin) and oxidative stress markers (8-oxodG, LOOH, MDA, CP).
  • Measured glucose as a metabolic marker.

Main Results:

  • Women with excessive GWG had lower adiponectin levels.
  • Adiponectin correlated with 8-oxodG in adequate/insufficient GWG groups, but not in excessive GWG.
  • Leptin was positively associated with oxidative markers (LOOH, MDA, CP) in excessive GWG.

Conclusions:

  • Adipokine production and oxidative stress are concurrently regulated in pregnancy.
  • Gestational weight gain, particularly excessive gain, influences this regulation.
  • Excessive adipose tissue accumulation likely plays a role in these altered associations.
Abstract

Keywords:
AdipokinesGestational weight gainOxidative stress

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