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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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The correlation of blood pressure variability and cognitive function in hypertension patients: A meta-analysis

Xiaojie Jin1, Yi Lu1, Peng Zhao1

  • 1Department of Neurology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

International Journal of Clinical Practice
|September 18, 2021
PubMed

Insights

Cognitive impairment (CI) in hypertension patients is linked to higher blood pressure variability. Managing blood pressure variability may help reduce CI occurrence in these individuals.

Area of Science:

  • Cardiology
  • Neurology
  • Gerontology

Background:

  • Cognitive impairment (CI) is a frequent complication in hypertensive patients.
  • Understanding the relationship between blood pressure variability (BPV) and CI is crucial for effective clinical management.
  • This meta-analysis aims to consolidate evidence on the association between BPV and cognitive function in hypertension.

Approach:

  • A systematic literature search was conducted on PubMed and other databases for case-control studies up to July 2021.
  • Data extraction and screening were performed independently by two researchers.
  • Meta-analysis was performed using RevMan 5.3 to synthesize findings from 13 studies involving 2754 patients.

Key Points:

  • Meta-analysis revealed significantly higher 24-hour systolic and diastolic blood pressure variation coefficients in patients with CI compared to those without.
  • Patients with CI exhibited significantly higher standard deviations and mean values for systolic and diastolic blood pressure variation.
  • No significant differences were found in morning peak blood pressure drop between groups with and without CI.

Conclusions:

  • Hypertensive patients with cognitive impairment demonstrate a strong association with increased blood pressure variability.
  • Clinical healthcare providers should prioritize the management of blood pressure variability in hypertensive individuals to mitigate the risk of cognitive impairment.
Abstract

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