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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Microbiota and prostate cancer.

Alessandro Rizzo1, Matteo Santoni2, Veronica Mollica1

  • 1Medical Oncology, IRCCS Azienda Ospedaliero, Universitaria di Bologna, Via Albertoni - 15, Bologna, Italy.

Seminars in Cancer Biology
|September 18, 2021
PubMed
Summary
This summary is machine-generated.

The gut microbiome may influence prostate cancer development and treatment response. Further research is needed to understand these interactions and explore microbiome-targeted therapies for prostate cancer.

Keywords:
Genitourinary cancersGenitourinary microbiomeMicrobiomeMicrobiotaProstate cancer

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Area of Science:

  • Oncology
  • Microbiome Research
  • Genitourinary Malignancies

Background:

  • Prostate cancer is a leading cause of cancer-related death globally.
  • The role of the microbiota in cancer development and treatment response is increasingly recognized.
  • Limited data exist on the prostate cancer-microbiome interaction, particularly concerning disease progression and therapeutic outcomes.

Purpose of the Study:

  • To review current knowledge on the gastrointestinal and genitourinary microbiome in prostate cancer.
  • To highlight novel insights into the microbiome's impact on prostate cancer pathogenesis.
  • To explore emerging therapeutic strategies targeting the microbiome for prostate cancer treatment.

Main Methods:

  • Literature review of existing studies and clinical trials.
  • Analysis of current evidence on microbiome composition and function in prostate cancer patients.
  • Synthesis of data on the influence of microbiota on treatment efficacy (chemotherapy, immunotherapy, targeted therapy).

Main Results:

  • Growing evidence suggests microbiota influence cancer development and treatment efficacy in various cancers.
  • Specific microbial signatures may be associated with prostate cancer development and progression.
  • The microbiome's impact on response to prostate cancer therapies is an active area of investigation.

Conclusions:

  • The gut and genitourinary microbiome represent a promising area for understanding and treating prostate cancer.
  • Further research is crucial to elucidate the complex interactions between the microbiome and prostate cancer.
  • Microbiome-based therapeutic approaches hold potential for improving patient outcomes in prostate cancer.