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[Epidemiologic study of atopic environment in Lorraine]
D A Moneret-Vautrin1, F Schiele, J Locuty
1Service de Médecine "D", C.H.U., Vandoeuvre-Lès-Nancy.
Allergie Et Immunologie
|May 1, 1986
Summary
This study found significant links between clinical atopy, positive allergy skin tests, and elevated immunoglobulin E (IgE) levels in children. These findings highlight the importance of allergy testing for diagnosing atopic conditions.
Area of Science:
- Pediatric Allergy and Immunology
- Epidemiology of Allergic Diseases
- Clinical Atopy Research
Context:
- An epidemiological study investigated atopy prevalence in 505 healthy children aged 4-14.
- Clinical atopy was assessed via questionnaires on atopic dermatitis, asthma, and hay fever.
- Allergen sensitization was evaluated using serum IgE levels and skin prick tests.
Purpose:
- To determine the prevalence of clinical atopy and allergen sensitization in a pediatric cohort.
- To explore correlations between clinical manifestations, skin test reactivity, and serum IgE levels.
- To identify potential risk factors associated with atopy in children.
Summary:
- Clinical atopy was diagnosed in 14.46% of children, with positive skin prick tests in 14.85%.
- Significant associations were found between clinical atopy, positive skin tests, and elevated serum IgE levels (>474 kUI/l).
- Recurrent infections, paternal atopy, and maternal atopy showed close relations with childhood atopy and IgE levels.
Impact:
- Establishes a strong correlation between clinical atopy, immunological markers (IgE), and environmental allergen sensitivity.
- Suggests that skin tests and serum IgE assays are comparable methods for investigating atopic predisposition.
- Identifies potential risk factors, including breastfeeding in non-atopic mothers, warranting further investigation.