Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A continuous differential evolution algorithm for solving uncapacitated facility location problems.

Scientific reports·2026
Same author

AS1411 aptamer-functionalized, cell membrane-camouflaged nanoparticles for targeted tumor cells imaging in the Raman silent region.

Analytical and bioanalytical chemistry·2026
Same author

From Lab to Ocean: Multiscale Design of Electrocatalysts for Practical Seawater Splitting Applications.

ChemSusChem·2026
Same author

Targeting CD30L Alleviates Airway Remodeling via JNK/p38 MAPK Pathway in OVA-Induced Asthmatic Mice.

Allergy, asthma & immunology research·2026
Same author

Room-temperature hydrogen storage of boron nanoclusters.

Nature nanotechnology·2026
Same author

Fast and sensitive spatial proteomics using laser capture microdissection and a protein immobilization-based capillary microreactor.

Analytica chimica acta·2026

Related Experiment Video

Updated: Oct 19, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

14.0K

Microliter-level multi-channel fraction collector for high-throughput separation system.

Xuantang Wang1, Mingxia Gao1, Xiangmin Zhang1

  • 1Department of Chemistry, Fudan University, Shanghai 200433, China.

Journal of Chromatography. A
|September 19, 2021
PubMed
Summary

Researchers developed a 3D-printed multi-channel fraction collector for high-performance liquid chromatography (HPLC). This affordable, customizable device enables high-throughput, microliter-level fraction collection for diverse analytical needs.

Keywords:
3D printingFraction collectorHPLCHigh-throughput separationMulti-channel separation

More Related Videos

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

27.8K
Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.5K

Related Experiment Videos

Last Updated: Oct 19, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

14.0K
Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

27.8K
Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.5K

Area of Science:

  • Analytical Chemistry
  • Chromatography
  • 3D Printing Applications

Background:

  • High-performance liquid chromatography (HPLC) is crucial for analytical applications.
  • High-throughput analysis requires multi-channel fraction collection, a capability not yet commercialized.
  • Existing fraction collection methods may not meet the demands for speed and precision in multi-channel separations.

Purpose of the Study:

  • To design and fabricate a novel multi-channel fraction collector using 3D-printing technology.
  • To enable high-throughput, microliter-level fraction collection for various HPLC applications.
  • To provide an affordable and customizable solution for researchers.

Main Methods:

  • Fabrication of a multi-channel fraction collector primarily using 3D-printed parts.
  • Integration of an automated controller and custom programs for automated operation.
  • Adaptation of the collector for narrow-bore, capillary, and conventional HPLC columns.

Main Results:

  • Successful development of a 3D-printed multi-channel fraction collector.
  • Demonstrated high accuracy microliter-level fraction cutting.
  • Capability to collect hundreds of fractions within 1 hour for high-throughput separation.

Conclusions:

  • The 3D-printed multi-channel fraction collector is a powerful, low-cost tool for high-throughput separation.
  • The customizable and accessible design allows researchers to build the device in their own labs.
  • This innovation supports further advancements in automated and high-throughput analytical separations.