Related Experiment Video
Updated: Oct 19, 2025
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Contact allergy in a paediatric population observed in a tertiary referral centre in Belgium
Esther Noë1, Sara Huygens1, Marie-Anne Morren2
1Department of Dermatology, Contact Allergy Unit, University Hospitals of Leuven, Leuven, Belgium.
Insights
Contact allergy is common in children with eczema. Patch testing revealed frequent positive reactions, particularly in those with atopic dermatitis, highlighting the importance of allergy evaluation.
Area of Science:
- Pediatric Dermatology
- Allergology
- Contact Dermatitis
Background:
- Contact allergy is a growing concern in pediatric eczema cases.
- Identifying specific allergens is crucial for effective management.
Purpose of the Study:
- To analyze patch test results in children over a decade.
- To evaluate demographic data, lesion sites, and allergen frequencies.
- To investigate the link between contact allergy and atopic dermatitis (AD).
Main Methods:
- Retrospective analysis of 329 children patch tested between 2010-2019.
- Utilized European baseline series, other relevant series, and personal products.
- Data included demographics, lesion locations, and patch test outcomes.
Main Results:
- 36% of children had at least one positive patch test reaction.
- Children with atopic dermatitis showed a higher prevalence of positive reactions.
- Common allergens included nickel sulfate, linalool hydroperoxide, limonene hydroperoxide, and para-phenylenediamine.
Conclusions:
- Contact allergy is frequently diagnosed in children with eczema.
- Patch testing is essential for identifying allergens in this population.
- Findings confirm the need for systematic allergy assessment in pediatric eczema.
Background:
Contact allergy is increasingly recognized as being important in children with eczema.
Objectives:
To retrospectively analyse the patch test results in children over the past 10 years, aiming to (1) evaluate demographic characteristics and lesion locations, (2) describe frequencies of positive patch test reactions, and (3) investigate the relationship with atopic dermatitis (AD).
Methods:
A total of 329 children were patch tested between January 2010 and December 2019 with the European (children) baseline series and/or other series, and the personal product(s) used.
Results:
A total of 119 (36%) children presented with at least one positive reaction. Children with AD had a higher prevalence of positive reactions compared with the non-AD group (P = .002), but without statistically significant difference regarding sensitization to more than one hapten (P = .39). The face (20.2%), hands (19.3%), feet (16.8%), arms (12.6%), and body folds (10.9%) were the most common sites of primary localizations. The most frequent contact allergens were nickel sulfate and linalool hydroperoxide (both 16%), limonene hydroperoxide (13.5%), and para-phenylenediamine (10.9%). No statistically significant difference for nickel sulfate was found between the AD and non-AD group (P = .20).
Conclusions:
Contact allergy in children with eczema was frequently observed in our tertiary referral centre in Belgium as well, confirming the need for patch testing.
More Related Videos
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
07:10Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
Published on: April 21, 2019
Related Concept Videos
02:06Allergic Reactions
01:27Allergic Drug Reactions