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The association between malaria prevalence and COVID-19 mortality
1Department of Community Health, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda. mustil4god@gmail.com.
BMC Infectious Diseases
|September 20, 2021
Summary
Countries with higher malaria prevalence reported fewer COVID-19 deaths. This suggests a potential protective association between malaria endemicity and coronavirus disease 2019 (COVID-19) mortality, warranting further investigation.
Area of Science:
- Epidemiology
- Global Health
Background:
- COVID-19 (coronavirus disease 2019) has caused a global increase in mortality.
- Despite poor healthcare systems, low- and middle-income countries reported fewer deaths than high-income nations.
- This discrepancy prompted an investigation into factors influencing COVID-19 mortality.
Purpose of the Study:
- To investigate the association between malaria prevalence and COVID-19 mortality.
- To identify key predictors of COVID-19 mortality across different countries.
Main Methods:
- An ecological study analyzed data from 195 countries.
- Spearman's correlation assessed associations between population variables and COVID-19 mortality.
- A generalized linear model with Poisson distribution identified significant predictors.
Main Results:
- Malaria prevalence showed a significant negative correlation with COVID-19 mortality.
- Median age, life expectancy, and 65+ mortality were positively correlated with COVID-19 mortality.
- Malaria prevalence, life expectancy, and mortality rate were significant predictors in multivariate analysis.
Conclusions:
- Findings support the hypothesis of reduced COVID-19 deaths in malaria-endemic regions.
- The study suggests a potential protective effect of malaria endemicity against COVID-19 mortality.
- Further clinical trials are recommended to validate these epidemiological findings.
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