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Published on: December 15, 2023
Neurological Effects of COVID-19 in Children
Tuhina Govil-Dalela1, Lalitha Sivaswamy2
1Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA; Department of Neurology, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA; Department of Pediatric Neurology, Children's Hospital of Michigan Specialty Center, 2nd Floor, 3950 Beaubien Street, Detroit, MI 48202, USA.
Insights
This review details the neurological effects of COVID-19 in children, covering symptoms, causes, and treatments. It also addresses managing neuroimmunologic conditions alongside COVID-19 therapies.
Area of Science:
- Neurology
- Infectious Diseases
- Pediatrics
Background:
- The COVID-19 pandemic significantly impacted global health in 2020.
- While adults were primarily affected, children also experienced COVID-19, with varied clinical presentations.
- Neurologic manifestations in pediatric COVID-19 cases required further investigation.
Purpose of the Study:
- To comprehensively review the neurologic manifestations of COVID-19 in children.
- To elucidate the epidemiology, pathogenesis, and clinical features of pediatric neurologic COVID-19.
- To discuss diagnostic findings, treatment strategies, and management of co-occurring neuroimmunologic disorders.
Main Methods:
- Literature review of studies on pediatric COVID-19 and neurologic symptoms.
- Analysis of epidemiological data, pathogenic mechanisms, and clinical case reports.
- Synthesis of information on laboratory and imaging findings, treatment options, and drug interactions.
Main Results:
- COVID-19 presents with diverse neurologic symptoms in children.
- Understanding pathogenesis is crucial for effective management.
- Specific considerations exist for neuroimmunologic comorbidities and polypharmacy.
Conclusions:
- Pediatric COVID-19 can involve significant neurologic complications.
- Integrated management strategies are essential for affected children.
- Further research is needed on long-term neurologic outcomes and drug interactions.
Abstract:
The COVID-19 pandemic has spread rapidly across the world in 2020, affecting both adults and, to a lesser extent, children. In this article, the authors describe the neurologic manifestations of COVID-19 in children, including the epidemiology, pathogenesis, clinical features, laboratory and imaging findings, and treatment options. The management of patients with concomitant neuroimmunologic disorders and drug interactions between medications used to treat COVID-19 and other neurologic disorders (especially immune-modifying drugs) is also discussed.
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