Related Experiment Video
Updated: Oct 19, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Elderly-onset adult Still's disease
Anis Mzabi1, Rym Fakhfakh1, Maissa Thabet1
1Department of Internal Medicine, Sahloul University Hospital, Sousse, Tunisia.
Elderly-onset Still's disease (EOSD) can present with severe complications and rare lung involvement. This review discusses EOSD and interstitial lung disease based on literature and case studies.
Area of Science:
- Rheumatology
- Pulmonology
- Internal Medicine
Background:
- Adult-onset Still's disease (AOSD) typically affects young adults but can occur in the elderly (EOSD).
- EOSD diagnosis often relies on criteria like the Yamaguchi criteria.
- Elderly patients may experience a more severe disease course and increased complications.
Observation:
- Interstitial lung disease is an uncommon manifestation of Still's disease.
- This article reviews the literature on EOSD and its association with interstitial lung changes.
- It also presents case studies from a single center.
Findings:
- EOSD in the elderly can lead to significant morbidity.
- Lung involvement, though rare, is a serious complication that requires careful monitoring.
- The clinical presentation and management of EOSD with interstitial lung disease warrant further investigation.
Implications:
- Increased awareness of EOSD and its potential pulmonary manifestations is crucial for early diagnosis and management in the elderly.
- Further research is needed to understand the pathogenesis and optimize treatment strategies for EOSD-associated interstitial lung disease.
- This review highlights the importance of a multidisciplinary approach involving rheumatologists and pulmonologists for affected patients.
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease I: Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...

