Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

4.2K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.2K
Microtubules in Signaling01:22

Microtubules in Signaling

1.8K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.8K
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

6.7K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
6.7K
Specialized Care Centers and Settings-II01:30

Specialized Care Centers and Settings-II

802
Rural Health Centers
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
802
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.0K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.0K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

249
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
249

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical practice recommendations for the diagnosis and management of nephropathic cystinosis.

Nature reviews. Nephrology·2026
Same author

Clinical and genetic heterogeneity of syndromic hearing loss and its non-syndromic hearing loss mimics.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Access to lymphangioleiomyomatosis care across Europe: an ERN-LUNG survey of clinical practice, and the case for a European registry and trial network.

ERJ open research·2026
Same author

ERS technical standard on reference values for cardiopulmonary exercise testing: summary report and a call for action.

The European respiratory journal·2026
Same author

Feasibility of the development and psychometric properties of a standardized screening instrument for mental disorders in patients with suspected rare diseases: results of the ZSE-DUO study.

Frontiers in psychiatry·2025
Same author

Physical fitness and clinically assessed disease burden in long-term childhood cancer survivors-The SURfit study.

Cancer·2025

Related Experiment Video

Updated: Oct 19, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.9K

[Centers for rare diseases-Structures, tasks and networks].

Helge Hebestreit1

  • 1Zentrum für Seltene Erkrankungen - Referenzzentrum Nordbayern, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Deutschland.

Gefasschirurgie : Zeitschrift Fur Vaskulare Und Endovaskulare Chirurgie : Organ Der Deutschen Und Der Osterreichischen Gesellschaft Fur Gefasschirurgie Unter Mitarbeit Der Schweizerischen Gesellschaft Fur Gefasschirurgie
|September 20, 2021
PubMed
Summary
This summary is machine-generated.

Specialized centers provide optimal care for rare diseases through interdisciplinary teams and research. Challenges include sustainable financing and telemedical infrastructure development for better networking.

Keywords:
German reference centersInterdisciplinaryNetworkTelemedicineType A centers

More Related Videos

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
07:56

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

3.0K
Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function
09:25

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

12.5K

Related Experiment Videos

Last Updated: Oct 19, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.9K
Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
07:56

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

3.0K
Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function
09:25

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

12.5K

Area of Science:

  • Rare disease research and treatment
  • Medical center management
  • Healthcare policy

Context:

  • Rare disease patients require specialized, interdisciplinary care.
  • Germany has over 30 Type A reference centers at university hospitals.
  • These centers collaborate with Type B centers, networks, and patient organizations.

Purpose:

  • To describe the structure and function of specialized rare disease centers in Germany.
  • To highlight the collaborative efforts and research involvement of these centers.
  • To identify current challenges in rare disease center operations.

Summary:

  • Specialized centers with interdisciplinary teams offer optimal treatment for rare diseases.
  • These centers engage in research and education, collaborating nationally and internationally.
  • Key challenges involve sustainable financing and establishing telemedical networks.

Impact:

  • Improved patient outcomes through specialized, coordinated care.
  • Advancement of rare disease knowledge through dedicated research and education.
  • Potential for enhanced collaboration and resource sharing via telemedical infrastructure.