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Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway

Qianqian Yin1, Longyun Wang1, Haiyang Yu2

  • 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Frontiers in Pharmacology
|September 20, 2021
PubMed

Insights

Polyphenols like curcumin and quercetin can modulate the Janus kinase-STAT (JAK-STAT) signaling pathway, offering potential for treating inflammatory and other diseases. This review explores over 20 phytochemicals targeting this crucial pathway.

Area of Science:

  • Molecular Biology
  • Immunology
  • Pharmacology

Background:

  • The Janus kinase-STAT (JAK-STAT) signaling pathway is integral to cytokine signaling, regulating cell proliferation, apoptosis, differentiation, and inflammatory responses.
  • It plays a critical role in innate and adaptive immunity, controlling inflammatory processes.
  • Limitations exist in monotherapy targeting of the JAK-STAT pathway due to its complex interactions, with most STAT-targeting drugs in preclinical stages.

Purpose of the Study:

  • To review the pharmacological effects of various polyphenolic phytochemicals on the JAK-STAT signaling pathway.
  • To explore the potential of natural compounds in modulating aberrant JAK-STAT activation for therapeutic benefit.

Main Methods:

  • Literature review focusing on phytochemicals and their interactions with the JAK-STAT pathway.
  • Analysis of over 20 kinds of polyphenolic phytochemicals based on their chemical structures.
  • Summary of reported pharmacological effects, including anti-inflammatory, antitumor, and cardiovascular benefits.

Main Results:

  • Curcumin, quercetin, and other plant polyphenols demonstrate multi-site inhibition of abnormal JAK-STAT pathway activation.
  • Polyphenols exhibit significant therapeutic potential in managing inflammatory conditions, cancer, and cardiovascular diseases via JAK-STAT modulation.
  • The review categorizes and discusses the effects of numerous phytochemicals based on their chemical structures.

Conclusions:

  • Polyphenolic phytochemicals represent a promising class of compounds for targeting the JAK-STAT pathway.
  • Natural compounds offer a viable strategy to overcome the limitations of current JAK-STAT targeted therapies.
  • Further research into these phytochemicals could lead to novel therapeutic agents for a range of diseases.
Keywords:
JAKSTATphytochemicalspolyphenolssignaling pathway

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