Related Experiment Video

Updated: Aug 12, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Osteomyelitis and septic arthritis in premature infant

B Goldstein1, P Manolas, J W Silver

  • 1Department of Surgery, Methodist Hospital, Brooklyn, NY.

Orthopaedic Review
|July 1, 1987
PubMed

Insights

A premature infant with Pseudomonas aeruginosa knee sepsis was treated with antibiotics and joint aspiration. Surgical intervention ultimately cured the infection, restoring full knee mobility.

Area of Science:

  • Neonatal Medicine
  • Pediatric Infectious Diseases
  • Orthopedic Surgery

Background:

  • Premature infants born at 26 weeks' gestation face significant health risks, including anemia, hyperbilirubinemia, and respiratory distress syndrome.
  • Neonatal sepsis is a serious condition requiring prompt and effective treatment.

Observation:

  • A 68-day-old premature infant developed Pseudomonas aeruginosa sepsis in her right knee.
  • Initial treatment involved daily knee aspirations, antibiotic joint instillation, and intravenous antibiotics.

Findings:

  • The infant showed no improvement after two weeks of conservative treatment.
  • Surgical incision and drainage, combined with continued intravenous antibiotics, led to a complete resolution of the knee infection.

Implications:

  • Early and aggressive surgical intervention may be crucial for treating neonatal Pseudomonas aeruginosa septic arthritis.
  • Successful treatment restored the infant's full range of motion, highlighting the importance of comprehensive care in neonatal sepsis.

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