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Updated: Oct 19, 2025
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Expression of miR-92a in colon cancer tissues and its correlation with clinicopathologic features and prognosis
Xiang Wu1, Xiaoxia Cui1, Chundi Yue1
1Department of Supervision and Treatment, Haikou People's Hospital, Hainan Province Prison Hospital Haikou 570208, Hainan, China.
Objective:
This study analyzed the expression of miR-92a in colon tumor tissues and its correlation with disease clinicopathologic features and prognosis.
Methods:
83 cases of colorectal cancer tissues and paracancerous normal tissues acquired from colon cancer resection surgery during January 2015-January 2017 were collected. We detected the expression of miR-92a in cancer tissues and paracancerous tissues by qRT-PCR, and analyzed the correlation between the relative expression of miR-92 in colon cancer tissues and clinicopathologic characteristics, progression-free survival (PFS), and overall survival (OS) of the patients accordingly.
Results:
The relative expression level of miR-92a in colon cancer tissues was higher than of paracancerous tissues (P<0.05). Relative expression of miR-92a in cancer was correlated with the degree of differentiation, TNM stage, and lymph node metastasis (P<0.05), while uncorrelated with gender, age, tumor diameter, or invasion depth (P>0.05). Patients with low expression of miR-92a had superior PFS to the control group (P>0.05) and better OS (P<0.05).
Conclusion:
Abnormally high expression of miR-92a occurs in colon tumor tissues. Its expression is related to the occurrence, progression, and prognosis of patients with colon cancer. It may be a marker for diagnosis, treatment, and prognosis of disease.
