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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Immune response to SARS-CoV-2 in children: A review of the current knowledge

Filippos Filippatos1, Elizabeth-Barbara Tatsi1, Athanasios Michos1

  • 1First Department of Pediatrics Infectious Diseases and Chemotherapy Research Laboratory Medical School National and Kapodistrian University of Athens "Aghia Sophia" Children's Hospital Athens Greece.

Pediatric Investigation
|September 20, 2021
PubMed

Insights

Children

Area of Science:

  • Immunology
  • Virology
  • Pediatrics

Background:

  • Host immune responses to SARS-CoV-2 are under investigation, particularly in children.
  • Children with COVID-19 rarely experience severe illness, hospitalization, or complications like MIS-C.
  • Understanding pediatric immune responses can reveal protective mechanisms and therapeutic targets.

Purpose of the Study:

  • To compare innate and adaptive immunity to SARS-CoV-2 between children and adults.
  • To explore reasons for the generally asymptomatic nature of COVID-19 in children.
  • To identify unresolved questions in pediatric immunology related to SARS-CoV-2.

Main Methods:

  • Review and comparison of existing immunological data on SARS-CoV-2 in children and adults.
  • Analysis of factors contributing to milder disease presentation in pediatric populations.
  • Identification of knowledge gaps in pediatric COVID-19 immunology.

Main Results:

  • Innate immunity plays a crucial role in the early stages of SARS-CoV-2 infection.
  • Adaptive memory immunity is essential for preventing reinfection.
  • Evidence suggests distinct immunological responses in children compared to adults.

Conclusions:

  • Pediatric immune responses to SARS-CoV-2 differ from adults, contributing to milder disease.
  • Innate and adaptive immunity are key components of host defense against SARS-CoV-2.
  • Further research is needed to fully elucidate pediatric immune responses and inform therapies.

Keywords:
COVID‐19ChildrenImmunityMultisystem inflammatory syndromeSARS‐CoV‐2

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