Interesting Presentation of Oral Herpes Simplex Virus in a High-Risk Patient

Orolabial and genital herpes are common conditions caused by herpes simplex virus (HSV) that affect many individuals. Although skin findings may mimic other conditions, an HSV infection may still be diagnosed clinically. We present a case of polymerase chain reaction (PCR) negative orolabial herpes in a young male with a high-risk social history. Although testing was negative, oral HSV was clinically diagnosed and the patient was adequately treated with IV acyclovir. Both clinical history and physical examination are essential to provide an accurate diagnosis even in cases presenting with a negative diagnostic test result.