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Impact of Precision Medicine on Clinical Outcomes: A Single-Institution Retrospective Study

Ryann Quinn1, Rajvi Patel1, Cristina Sison2,3

  • 1Northwell Health Cancer Institute, New Hyde Park, NY, United States.

Frontiers in Oncology
|September 20, 2021
PubMed
Abstract

Insights

Precision medicine shows promise in oncology, with targeted therapies improving outcomes for patients with actionable genetic alterations. Further research is needed to confirm these findings in larger, prospective studies.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Precision medicine is increasingly used in oncology, but its real-world effectiveness requires further evaluation.
  • FoundationOne CDx™ (F1CDx) testing identifies actionable genomic alterations to guide targeted therapy selection.

Purpose of the Study:

  • To assess clinical outcomes in cancer patients receiving targeted therapy based on F1CDx results.
  • To evaluate the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) in this patient cohort.

Main Methods:

  • Retrospective cohort study of 1000 patients undergoing F1CDx testing between September 2012 and July 2018.
  • Identified 652 patients with actionable mutations; 38 patients received targeted therapy and were included in the analysis.
  • Primary endpoint: ORR at 3 months. Secondary endpoints: PFS and OS.

Main Results:

  • The most common alterations included PD-1/PDL-1, high-TMB, P13K, and HER2/ERBB2.
  • Among 38 patients, 23.5% achieved partial response (PR) and 17.7% had stable disease (SD), resulting in a 41.2% disease control rate.
  • Median PFS was 2.7 months and median OS was 9.9 months.

Conclusions:

  • Real-world data suggest potential benefits of precision medicine and targeted therapies in oncology.
  • Further large-scale, prospective studies are warranted to validate these promising findings in patients with actionable genomic alterations.
Keywords:
FoundationOnenext-generation sequencingprecision medicineprecision oncologytargeted treatment approaches

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