Related Experiment Video

Updated: Oct 19, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.2K

The Hippo pathway: an emerging role in urologic cancers

Bekir Cinar1, Esma Alp1, Marwah Al-Mathkour1

  • 1The Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University Atlanta, Georgia, USA.

American Journal of Clinical and Experimental Urology
|September 20, 2021
PubMed

Insights

The Hippo pathway regulates cell growth and organ size. Inhibiting YAP1/TEAD signaling, often dysregulated in cancers like prostate, kidney, and bladder, offers therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • The Hippo pathway is a crucial regulator of cell proliferation, differentiation, and organ size.
  • Core kinases MST1/2 and LATS1/2 inactivate YAP1 signaling.
  • Dysregulation of the Hippo pathway, particularly YAP1/TEAD signaling, is implicated in various cancers.

Purpose of the Study:

  • To review the components of the Hippo pathway.
  • To examine the role of the Hippo pathway in prostate, kidney, and bladder cancers.
  • To explore the therapeutic potential of targeting YAP1/TEAD signaling in these cancers.

Main Methods:

  • Literature review of Hippo pathway components.
  • Analysis of Hippo pathway involvement in genitourinary cancers.
  • Evaluation of therapeutic strategies targeting YAP1/TEAD.

Main Results:

  • Loss of MST1/2 and LATS1/2 function correlates with cancer progression.
  • Activated YAP1/TEAD signaling contributes to oncogenesis in these cancers.
  • Targeting YAP1/TEAD presents a promising therapeutic avenue.

Conclusions:

  • The Hippo pathway is vital in controlling cellular processes and organ development.
  • Aberrant YAP1/TEAD signaling drives tumorigenesis in prostate, kidney, and bladder cancers.
  • Inhibiting YAP1/TEAD signaling holds significant therapeutic promise for treating these malignancies.
Keywords:
Hippo pathwayLATS1LATS2MST1/STK3MST1/STK4YAP1cancer biologysignal transductionurologic cancer

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