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Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy
Guangqiang Li1,2, Xiaoyan Zhong3, Xianwen Wang2
1College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Bioactive Materials
|September 20, 2021
Summary
Defective Ti3C2 MXene nanosheets (H-Ti3C2 NSs) enhanced sonodynamic therapy (SDT) efficiency by 3.7-fold. Mild photothermal effects improved cancer treatment by enhancing SDT and relieving tumor hypoxia, with no observed long-term toxicity.
Area of Science:
- Biomedical engineering
- Materials science
- Nanotechnology
Background:
- Sonodynamic therapy (SDT) is a promising noninvasive cancer treatment using ultrasound (US).
- MXene-based nanomaterials offer potential as sonosensitizers due to their unique properties.
- Improving the efficiency and safety of SDT is crucial for clinical translation.
Purpose of the Study:
- To develop high-efficiency and safe sonosensitizers for photothermal-enhanced SDT.
- To investigate the role of oxygen defects in Ti3C2 MXene nanosheets for enhanced sonodynamic performance.
- To evaluate the combined effects of photothermal therapy (PTT) and SDT using modified MXene nanosheets in cancer treatment.
Main Methods:
- Ti3C2 MXene nanosheets (NSs) were synthesized and treated at high temperatures to increase oxygen defects, creating H-Ti3C2 NSs.
- PEGylation was performed to enhance stability and biocompatibility, yielding H-Ti3C2-PEG NSs.
- In vitro and in vivo studies were conducted to assess SDT efficacy, photothermal effects, and biocompatibility.
Main Results:
- High-temperature treatment significantly increased oxygen defects in Ti3C2 NSs, improving sonodynamic efficiency by approximately 3.7-fold.
- H-Ti3C2-PEG NSs demonstrated good stability and biocompatibility, with mild photothermal effects promoting cellular uptake and enhancing SDT efficacy.
- In vivo studies showed that PTT-enhanced SDT significantly relieved tumor hypoxia, indicating a synergistic therapeutic effect.
- Biodegradation and excretion studies confirmed no significant long-term toxicity of H-Ti3C2-PEG NSs.
Conclusions:
- Defective H-Ti3C2 NSs serve as highly efficient sonosensitizers for photothermal-enhanced SDT.
- The combination of PTT and SDT offers a promising strategy for cancer therapy by improving tumor microenvironment and efficacy.
- MXene-based nanoplatforms show significant potential for advanced biomedical applications in cancer treatment.
