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Engineering of biomaterials for tumor modeling
Sae Rome Choi1, Yi Yang2, Kai-Yu Huang3
1School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Materials Today. Advances
|September 20, 2021
Summary
Biomaterials engineering advances tumor models for drug discovery and cancer research. This review focuses on cellular, matrix, and microenvironmental engineering, particularly for pancreatic ductal adenocarcinoma (PDAC).
Area of Science:
- Biomaterials Science
- Cancer Biology
- Tissue Engineering
Background:
- Biomaterials engineering is crucial for developing advanced tumor models.
- These models mimic the tumor microenvironment for applications in drug discovery and precision medicine.
- Current engineered tumor models are often in early stages of development.
Purpose of the Study:
- To review the current status of biomaterials engineering for tumor models.
- To focus on cellular, matrix, and microenvironmental engineering aspects.
- To specifically address pancreatic ductal adenocarcinoma (PDAC) models.
Main Methods:
- Review of existing literature on biomaterials engineering for tumor models.
- Analysis of cellular engineering strategies.
- Evaluation of matrix engineering approaches.
- Assessment of microenvironmental condition engineering.
Main Results:
- Biomimetic models reconstitute tumor and stroma cells within 3D extracellular matrices.
- Models are increasingly tailored to recapitulate in vivo tumor microenvironments.
- Pancreatic ductal adenocarcinoma (PDAC) presents unique challenges and opportunities.
Conclusions:
- Significant progress has been made in engineering biomimetic tumor models.
- Further development is needed to enhance model reliability and relevance for cancer research.
- Future opportunities lie in addressing cancer-specific variability, especially for PDAC.
