Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

2.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
2.0K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

854
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
854
Language and Cognition01:27

Language and Cognition

509
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
509
Language Development01:22

Language Development

557
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
557
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

763
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
763
Neuroplasticity01:01

Neuroplasticity

940
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
940

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The usefulness of microbiome profiling for geriatric patients with neuropsychiatric conditions: a scoping review.

Translational psychiatry·2025
Same author

Susceptibility to visual hallucinations in the amyotrophic lateral sclerosis-frontotemporal dementia spectrum: The role of dysfunctional attentional networks.

Cortex; a journal devoted to the study of the nervous system and behavior·2025
Same author

Fourteen years later: Reviewing the diagnostic criteria for behavioral-variant frontotemporal dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders.

Brain communications·2025
Same author

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.

Nature communications·2025
Same author

Case Series of Right-Hemisphere Nonfluent Variant of Primary Progressive Aphasia.

Journal of clinical neurology (Seoul, Korea)·2025

Related Experiment Video

Updated: Oct 19, 2025

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

35.2K

Brain changes underlying progression of speech motor programming impairment.

Ramon Landin-Romero1,2, Cheng T Liang1,2, Penelope A Monroe3

  • 1School of Psychology, The University of Sydney, Sydney, NSW, Australia.

Brain Communications
|September 20, 2021
PubMed
Summary
This summary is machine-generated.

The pairwise variability index effectively tracks acquired apraxia of speech progression in primary progressive aphasia, particularly the non-fluent variant. This acoustic measure shows strong links to brain atrophy, highlighting the right frontal gyrus

Keywords:
apraxia of speechcortical thicknesslogopenic progressive aphasiaprimary progressive aphasiaprogressive nonfluent aphasia

More Related Videos

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.9K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.9K

Related Experiment Videos

Last Updated: Oct 19, 2025

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

35.2K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.9K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.9K

Area of Science:

  • Neuroscience
  • Speech-Language Pathology

Background:

  • Acquired apraxia of speech (AOS) impairs speech production despite intact motor function, with its underlying mechanisms unclear.
  • Primary progressive aphasia (PPA) variants, especially non-semantic ones, can present with AOS.
  • The normalized pairwise variability index (nPVI) is a sensitive acoustic marker for AOS.

Purpose of the Study:

  • To assess the efficacy of nPVI and articulation rate as markers for progressive speech motor programming deficits in PPA with AOS.
  • To investigate the longitudinal changes in speech production and their correlation with brain atrophy in PPA patients.

Main Methods:

  • Longitudinal study of 79 individuals with PPA (non-fluent and logopenic variants) and 40 controls over 1-6 years.
  • Speech assessments (nPVI, word duration) and high-resolution MRI were performed.
  • Analyses focused on speech production trajectories and associations with cortical atrophy.

Main Results:

  • Word duration initially differentiated PPA variants, but with significant overlap.
  • Longitudinal analysis revealed progressive deterioration in nPVI and word duration exclusively in the non-fluent PPA group.
  • nPVI strongly correlated with progressive atrophy in speech motor programming regions, notably the right frontal gyrus.

Conclusions:

  • nPVI is a robust and sensitive marker for tracking AOS progression in PPA, outperforming general speaking rate measures.
  • The findings highlight the role of the right frontal gyrus in speech motor programming and suggest its importance in non-fluent PPA.
  • Developing sensitive measures of rhythmic temporal control is crucial for early detection and monitoring of speech disturbances in neurodegenerative diseases.