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[Influenza vaccination and asthma].
J Miguères1, F Sallerin, R Zayani
1Service des Malades Respiratoires, CHU de Rangueil, Toulouse.
Allergie Et Immunologie
|January 1, 1987
Summary
Inactivated polyvalent vaccines may cause respiratory issues in asthma patients. A study found 24% experienced breathing difficulties, and some asthmatics showed altered bronchial reactivity post-vaccination.
Area of Science:
- Pulmonology
- Immunology
Background:
- Asthma patients may have unique responses to vaccinations.
- Respiratory tolerance to vaccines requires further investigation.
Purpose of the Study:
- To investigate the respiratory tolerance of inactivated vaccines in asthma patients.
- To assess bronchial reactivity and flow-volume curves after vaccination.
Main Methods:
- Retrospective case history review of 87 adults vaccinated.
- Prospective study of bronchial reactivity to carbachol (CBL) and flow-volume curves in controls and patients (asthma, COPD, tuberculosis sequelae) before and after vaccination.
Main Results:
- 24% of patients reported poor respiratory tolerance, including dyspnea and asthma exacerbations.
- Some controls and a significant portion of asthmatics (6/12) showed altered bronchial reactivity or flow-volume parameters post-vaccination.
Conclusions:
- Inactivated polyvalent vaccines may elicit adverse respiratory reactions in a subset of asthma patients.
- Further research is needed to understand the mechanisms and implications of these reactions.