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Updated: Oct 19, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

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Males with abdominal aortic aneurysm have reduced left ventricular systolic and diastolic function

Ida Åström Malm1, Rachel De Basso1, Jan Engvall2,3

  • 1Department of Natural Sciences and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Clinical Physiology and Functional Imaging
|September 20, 2021
PubMed

Insights

Abdominal aortic aneurysms (AAAs) are linked to impaired left ventricular systolic and diastolic function in men. This suggests AAA may represent a broader aortic disease affecting heart function.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Echocardiography

Background:

  • Abdominal aortic aneurysm (AAA) is a known risk factor for heart failure and cardiovascular events.
  • Limited understanding exists regarding left ventricular (LV) function in patients with AAA.

Purpose of the Study:

  • To investigate the association between AAA and left ventricular systolic and diastolic dysfunction using echocardiography.
  • To compare LV function in male patients with AAA against a control group.

Main Methods:

  • Echocardiography was performed on 307 males (199 with AAA, 108 controls) between 2011-2016.
  • Participants were recruited from AAA surveillance and screening programs.

Main Results:

  • Subjects with AAA exhibited thicker LV walls and reduced systolic function (lower ejection fraction and global longitudinal strain).
  • Diastolic dysfunction was indicated by decreased mitral annular plane systolic excursion and higher E/e' ratio in the AAA group.
  • Wider aortic sinus and ascending aorta diameters were observed in AAA patients compared to controls.

Conclusions:

  • Abdominal aortic aneurysms are associated with impaired left ventricular systolic and diastolic function in males.
  • The findings suggest that AAA may be part of a generalized aortic disease process, impacting cardiac function.
Abstract

Keywords:
AAAarteriescardiovascular risk assessmentechocardiographyleft ventricular dysfunction

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