Specific immunotherapy in hay fever

The observation included 120 patients suffering from hay fever (HF) in age 18-58. In 77 of them specific immunotherapy (SI) with pollen vaccine was applicated through 3 consecutive years, while 43 patients remained without this form of therapy, as a control group. SI was efficient in 47% of treated patients, and in these cases IgE value came back to normal value, the IgG level increased and suppression of skin test to pollen allergens was observed. In 17% of treated patients side effects appeared during SI and together with exacerbation of HF, an increase of skin reaction to pollen allergens was noted.