Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

953
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
953
Regional Terms01:12

Regional Terms

13.2K
Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...
13.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comment on "Diagnostic Guidance for Chronic Complex Regional Pain Syndrome Type I and Type II from The American Society of Interventional Physicians (ASIPP)".

Pain physician·2026
Same author

Quantitative sensory testing and classical pain model dataset in 127 healthy volunteers.

Data in brief·2026
Same author

Defining "regional" pain.

Pain·2026
Same author

Adamczyk et al. "Disrupted spatial but not temporal aspects of nociceptive processing determine painful polyneuropathies"-considerations for temporal contrast detection, stimulus site, and aetiology.

Pain·2026
Same author

Clinical Phenotypes and the Effects of Interdisciplinary Pain Treatment in Pediatric Complex Regional Pain Syndrome.

Pain practice : the official journal of World Institute of Pain·2026
Same author

Pain in multiple sclerosis: clinical phenotypes and therapeutic strategies - a narrative review.

Pain reports·2026

Related Experiment Video

Updated: Oct 19, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

7.9K

[Complex regional pain syndrome-An update].

Cora Rebhorn1, Violeta Dimova2, Frank Birklein2

  • 1Klinik und Poliklinik für Neurologie, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland. cora.rebhorn@unimedizin-mainz.de.

Der Nervenarzt
|September 20, 2021
PubMed
Summary

Complex regional pain syndrome (CRPS) is a pain disorder following injury, characterized by persistent inflammation. Treatment focuses on anti-inflammatory drugs, mobilization, and restoring limb function.

Keywords:
InflammationNeuronal plasticityNociceptionPainWounds and injuries

More Related Videos

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.0K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

2.3K

Related Experiment Videos

Last Updated: Oct 19, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

7.9K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.0K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

2.3K

Area of Science:

  • Pain Medicine
  • Neurology
  • Immunology

Background:

  • Complex regional pain syndrome (CRPS) is a debilitating pain disorder affecting limbs post-injury.
  • CRPS is classified into types I and II, with subtypes based on initial temperature presentation (warm or cold).
  • Physiological inflammation post-trauma can become persistent in CRPS, involving inflammatory mediators.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms of CRPS, focusing on persistent inflammation.
  • To outline current treatment strategies for CRPS.

Main Methods:

  • Review of existing literature on CRPS pathophysiology and treatment.
  • Analysis of inflammatory mediators and their role in CRPS.
  • Examination of nociceptive system sensitization and endothelial dysfunction.

Main Results:

  • Persistent inflammation in CRPS is maintained by peripheral and blood inflammatory mediators.
  • This inflammation leads to nociceptive sensitization, cell proliferation, and endothelial dysfunction.
  • CRPS involves complex interactions between inflammatory, nervous, and vascular systems.

Conclusions:

  • CRPS pathophysiology involves persistent inflammation, sensitization, and functional disruption.
  • Treatment strategies target antagonizing these pathophysiological components.
  • Effective management requires anti-inflammatory and analgesic treatments, alongside mobilization and functional restoration.