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Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges
Alireza Jenabi1, Rouhollah Mehdinavaz Aghdam2, S A Seyyed Ebrahimi1
1School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box: 11155-4563, Tehran, Iran.
Cardiovascular Toxicology
|September 20, 2021
Summary
Myocardial infarction (MI) treatment needs better oxygen delivery. This review discusses oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs) for improving cardiac tissue oxygenation after MI.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Regenerative Medicine
Background:
- Myocardial infarction (MI) is a leading cause of global mortality, characterized by reduced blood and oxygen supply to the heart.
- Hypoxemia post-MI causes significant cardiac cell death and impaired heart function.
- Current MI treatments often overlook the critical need for efficient oxygen delivery to injured cardiac tissue.
Purpose of the Study:
- To review and discuss oxygen delivery mechanisms for treating myocardial infarction.
- To provide a comprehensive overview of current technologies aimed at improving oxygen supply to the heart.
- To evaluate the efficacy and limitations of various oxygenation strategies in MI management.
Main Methods:
- Review of existing literature on oxygen delivery strategies for MI.
- Analysis of three primary technical approaches: oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs).
- Discussion of studies investigating these methods and their outcomes in animal and clinical settings.
Main Results:
- Oxygen therapy and HBOCs have demonstrated potential benefits in MI treatment but face limitations.
- Oxygen-releasing biomaterials (ORBs) are emerging as a promising strategy for cardiac tissue oxygenation.
- Comparative analysis highlights the advantages and challenges associated with each oxygen delivery approach.
Conclusions:
- Efficient oxygen delivery is crucial for effective myocardial infarction treatment.
- While oxygen therapy and HBOCs offer some therapeutic value, ORBs represent a potentially significant advancement.
- Further research into ORBs is warranted to overcome current challenges and optimize their role in future MI management.
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