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Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges

Alireza Jenabi1, Rouhollah Mehdinavaz Aghdam2, S A Seyyed Ebrahimi1

  • 1School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box: 11155-4563, Tehran, Iran.

Cardiovascular Toxicology
|September 20, 2021
PubMed

Insights

Myocardial infarction (MI) treatment needs better oxygen delivery. This review discusses oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs) for improving cardiac tissue oxygenation after MI.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Myocardial infarction (MI) is a leading cause of global mortality, characterized by reduced blood and oxygen supply to the heart.
  • Hypoxemia post-MI causes significant cardiac cell death and impaired heart function.
  • Current MI treatments often overlook the critical need for efficient oxygen delivery to injured cardiac tissue.

Purpose of the Study:

  • To review and discuss oxygen delivery mechanisms for treating myocardial infarction.
  • To provide a comprehensive overview of current technologies aimed at improving oxygen supply to the heart.
  • To evaluate the efficacy and limitations of various oxygenation strategies in MI management.

Main Methods:

  • Review of existing literature on oxygen delivery strategies for MI.
  • Analysis of three primary technical approaches: oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs).
  • Discussion of studies investigating these methods and their outcomes in animal and clinical settings.

Main Results:

  • Oxygen therapy and HBOCs have demonstrated potential benefits in MI treatment but face limitations.
  • Oxygen-releasing biomaterials (ORBs) are emerging as a promising strategy for cardiac tissue oxygenation.
  • Comparative analysis highlights the advantages and challenges associated with each oxygen delivery approach.

Conclusions:

  • Efficient oxygen delivery is crucial for effective myocardial infarction treatment.
  • While oxygen therapy and HBOCs offer some therapeutic value, ORBs represent a potentially significant advancement.
  • Further research into ORBs is warranted to overcome current challenges and optimize their role in future MI management.

Keywords:
Hemoglobin-based oxygen carriersHypoxemiaMyocardial infarctionOxygen deliveryOxygen therapyOxygen-releasing biomaterials

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