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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

8.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

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Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Thermal Ablation for the Treatment of Abdominal Tumors
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Ablation Techniques in Cancer Pain.

Jonathan Kessler1

  • 1Division of Interventional Radiology, Department of Diagnostic Radiology, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA, 91010, USA. jkessler@coh.org.

Cancer Treatment and Research
|September 20, 2021
PubMed
Summary

Painful bone metastases are common in cancer patients, affecting up to 85% with breast, prostate, and lung cancers. These skeletal metastases significantly impact patient quality of life.

Area of Science:

  • Oncology
  • Skeletal Metastasis Research

Background:

  • Painful bone metastases represent a significant clinical challenge in cancer care.
  • The skeletal system is a common site for metastatic spread, particularly in advanced cancers.
  • Up to 85% of patients with breast, prostate, and lung cancer may develop bone metastases.

Purpose of the Study:

  • To highlight the prevalence and clinical significance of painful bone metastases.
  • To underscore the impact of skeletal metastases on patient outcomes.

Main Methods:

  • Literature review on bone metastases prevalence.
  • Analysis of common cancer types associated with skeletal involvement.

Main Results:

  • Bone metastases are a frequent complication in oncology.

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  • Breast, prostate, and lung cancers show high rates of skeletal involvement.

    • Conclusions:

    • Painful bone metastases are a critical issue requiring effective management strategies.
    • Understanding the incidence in specific cancers is key for patient care.