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Updated: Oct 19, 2025
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Silent celiac disease in dermatology
Raúl Emilio Real-Delor1, Guillermo Aldama-Negrete1, Arnaldo Aldama-Caballero2
1Hospital Nacional, Departamento de Medicina Interna.
IntroduccióN:
La enfermedad celíaca puede estar asociada de forma silente a varias enfermedades de la piel y las mucosas.
Objetivo:
Determinar la frecuencia de enfermedad celíaca en portadores de urticaria crónica, vitíligo, alopecia areata, psoriasis y estomatitis aftosa, en el Hospital Nacional de Itauguá, Paraguay, en los años 2017 y 2018.
Material Y MéTodos:
Diseño observacional de corte transversal, prospectivo. Se determinaron los anticuerpos IgA antitransglutaminasa tisular e IgA sérica en pacientes adolescentes y adultos que otorgaron su consentimiento informado. En los casos positivos se realizó la confirmación histológica con biopsias duodenales.
Resultados:
Se incluyeron 79 pacientes, con predominio del sexo femenino (75%). La mediana de edad fue de 33 años y el índice de masa corporal medio fue de 24.7 kg/m2. La enfermedad celíaca se demostró histológicamente en 4 de 32 portadores de estomatitis aftosa, en 2 de 24 con vitíligo y en 1 de 17 con alopecia areata. No se detectó en pacientes con urticaria crónica ni psoriasis.
ConclusióN:
La frecuencia de enfermedad celíaca confirmada histológicamente en pacientes con estomatitis aftosa, vitíligo o alopecia areata fue del 8.8%.
Background:
Silent celiac disease may be associated to various skin and mucous membranes diseases.
Objective:
Determine the frequency of celiac disease in carriers of chronic urticaria, vitiligo, alopecia areata, psoriasis and aphthous stomatitis treated in the National Hospital of Itauguá, Paraguay, in years 2017 and 2018.
Material And Methods:
An observational cross-sectional, prospective design was used. IgA tissue antitransglutaminase antibody and serum IgA was determined in adolescents and adult patients who gave their informed consent. In positive cases, histological confirmation was performed with duodenal biopsies.
Results:
79 patients were included, with a predominance of females (75%). Median age was 33 years, and the average body mass index 24.7 kg/m2. Celiac disease was demonstrated histologically in 4/32 carriers of aphthous stomatitis, in 2/24 with vitiligo, and in 1/17 with alopecia areata. It was not detected in patients with chronic urticaria or psoriasis.
Conclusion:
Frequency of celiac disease histologically confirmed in patients with aphthous stomatitis, vitiligo or alopecia areata was 8.8%.
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