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Updated: Oct 19, 2025

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Two lymphomas in the same patient: A case report
Sergio Ignacio Moreno-Urbina1, Magda Mariana Medina-Ruiz2, Raquel Gámez-Elizarrarás2
1Instituto Mexicano del Seguro Social, Hospital General Regional No. 1, Servicio de Hematología.
IntroduccióN:
La asociación de forma sincrónica de un linfoma Hodgkin y un linfoma no Hodgkin en un mismo paciente es muy rara.
Caso ClíNico:
Varón de 68 años que comienza su padecimiento con adenomegalias cervicales y axilares. Se realiza biopsia escisional y se encuentra linfoma de Hodgkin de tipo celularidad mixta, por lo que se inicia quimioterapia. Durante el transcurso del tratamiento se observa la continuidad de lesiones refractarias en la piel y el músculo, por lo que el servicio de radiooncología decide hacer una nueva biopsia y se demuestra que se trata de una nueva afección, un linfoma no Hodgkin difuso de células B grandes.
Conclusiones:
Este caso ejemplifica que ante un paciente con un cuadro clínico típico y con una evolución tórpida hay que replantearse el diagnóstico e incluso repetir los estudios realizados para descartar diagnósticos alternos que puedan alterar el curso de la enfermedad.
Background:
The synchronous association of Hodgkin lymphoma and non-Hodgkin lymphoma in the same patient is very rare.
Case Report:
A 68 years old male patient who began his disease with cervical and axillary adenomegaly, it was performed an excisional biopsy and a mixed cell-type Hodgkin lymphoma was found. Chemotherapy with partial response was initiated. During the course of the treatment, refractory lesions were observed in skin and muscle. Radiation oncology service decided to make a second biopsy which confirms the presence of a large diffuse B cell non-Hodgkin lymphoma.
Conclusions:
This case is an example of how when you have a patient with a typical clinical picture of bad prognosis, the diagnosis should be reconsidered and laboratory studies previously done must be repeated to rule out alternative diagnoses that may change the course of the disease.
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