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Stroke-related alterations in inter-areal communication.

Michele Allegra1, Chiara Favaretto2, Nicholas Metcalf3

  • 1Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille 13005, France.

Neuroimage. Clinical
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Summary

Stroke disrupts brain network communication, reducing information transfer between hemispheres. This study quanties altered brain network dynamics after stroke, revealing hemispheric asymmetries and correlating them with cognitive deficits.

Keywords:
Granger causalityResting state fMRIStroke

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Stroke damages brain tissue and disrupts long-range anatomical connections.
  • Functional connectivity (FC) abnormalities after stroke correlate with behavioral deficits and recovery.
  • Standard FC analysis lacks directionality and time-scale information for inter-areal communication.

Purpose of the Study:

  • To quantify network-level information transfer and its alteration in stroke patients.
  • To investigate the directionality and time scale of inter-areal information transfer post-stroke.
  • To identify large-scale network anomalies and their correlation with behavioral deficits.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (fMRI).
  • Applied covariance-based Granger causality analysis to assess network-level information transfer.
  • Compared stroke patients with healthy controls to identify anomalies.

Main Results:

  • Stroke patients exhibited significantly decreased inter-hemispheric information transfer compared to controls.
  • Stroke induced inter-hemispheric asymmetries, with reduced information transfer within the affected hemisphere and from the affected to the intact hemisphere.
  • These anomalies were pronounced in attention and language networks and correlated with behavioral impairments.

Conclusions:

  • Stroke provokes significant asymmetries in brain network information transfer between hemispheres.
  • Reduced inter-hemispheric communication and intra-hemispheric transfer contribute to cognitive deficits post-stroke.
  • The functional consequences of stroke-induced asymmetries depend on the lesioned hemisphere.