Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chromatin Position Affects Gene Expression

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuromuscular junction biomarker CAF22 predicts functional decline in patients with chronic obstructive pulmonary disease.

Respiratory medicine·2026

Same author

Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network.

Annals of translational medicine·2026

Same author

Neuromuscular biomarkers are associated with sarcopenia and physical performance in chronic pancreatitis: An integrative biomarker profiling study.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2026

Same author

Agro-physiological responses and molecular docking evaluation of some essential oils and ascorbic acid as eco-friendly inhibitors of powdery mildew in cucumber plants.

Frontiers in plant science·2026

Same author

What you see is what you hear: microangioscopy-guided management of carotid-cochlear dehiscence in pulsatile tinnitus.

Journal of neurointerventional surgery·2026

Same author

Understanding DMG: current treatment options and prospective solutions using nanoparticles.

Drug delivery and translational research·2026

Search research articles

Related Experiment Video

Updated: Oct 19, 2025

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

Is the myonuclear domain ceiling hypothesis dead?

Ferdos Aman¹, Eman El Khatib¹, Alanood AlNeaimi¹

¹Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Singapore Medical Journal

|September 20, 2021

Summary

The myonuclear domain (MND) size may expand during muscle hypertrophy, but a definitive upper limit (MND ceiling) is debated. This review explores the MND ceiling hypothesis and its role in muscle adaptation.

Keywords:

Muscle hypertrophy myonuclear domain satellite cells skeletal muscle

More Related Videos

Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes

Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes

Published on: January 12, 2024

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Published on: May 12, 2016

Related Experiment Videos

Last Updated: Oct 19, 2025

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes

Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes

Published on: January 12, 2024

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Published on: May 12, 2016

Area of Science:

Muscle physiology
Cell biology
Skeletal muscle adaptation

Background:

Muscle fibers are multinucleated cells.
The myonuclear domain (MND) is the transcriptional territory controlled by a single myonucleus.
MND size is known to change with muscle hypertrophy.

Purpose of the Study:

To review the existing literature on the myonuclear domain (MND) ceiling hypothesis in muscle hypertrophy.
To discuss factors contributing to conflicting results in the literature regarding the MND ceiling.
To examine the physiological and clinical significance of the MND ceiling in muscle adaptation.

Main Methods:

Literature review of studies investigating myonuclear domain size and muscle hypertrophy.
Analysis of conflicting findings related to the MND ceiling hypothesis.
Synthesis of evidence from various physiological and pathological conditions.

Main Results:

The existence and extent of a "MND ceiling" during muscle hypertrophy remain debated.
Conflicting results exist regarding whether MND size reaches a limit before new myonuclei are required.
Factors influencing MND size regulation and the MND ceiling are complex and multifactorial.

Conclusions:

The MND ceiling hypothesis requires further investigation to reconcile conflicting findings.
Understanding the MND ceiling is crucial for comprehending muscle adaptation to growth and stress.
The physiological and clinical implications of MND size regulation are significant for muscle health and disease.