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Chenopodin as an anti-inflammatory compound.

Dávia Guimarães Pompeu1, Helon Guimarães Cordeiro2, Flávia Cristina Policarpo Tonelli1

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Summary

Chenopodin, a protein from quinoa seeds, was studied for its anti-inflammatory effects. This research found that Chenopodin effectively reduces swelling and immune cell activity in mouse models of inflammation.

Keywords:
ChenopodinChenopodium quinoaanti-inflammatory activityin vivoseeds

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Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Chenopodin is an 11S-type globulin isolated from *Chenopodium quinoa* seeds.
  • It possesses carbohydrate-binding and hemagglutinating properties.
  • The N-terminal structure and anti-inflammatory potential of Chenopodin were previously uncharacterized.

Purpose of the Study:

  • To elucidate the N-terminal structure of heterodimeric Chenopodin.
  • To investigate the *in vivo* anti-inflammatory effects of Chenopodin.
  • To determine Chenopodin's impact on edema and neutrophil recruitment.

Main Methods:

  • Purification of Chenopodin from *Chenopodium quinoa* seeds.
  • Analysis of the N-terminal structure and subunit composition.
  • Assessment of anti-inflammatory activity using a carrageenan-induced paw edema model in mice.
  • Quantification of neutrophil recruitment.

Main Results:

  • Chenopodin comprises two subunits with 92% N-terminal homology.
  • Administration of Chenopodin significantly reduced carrageenan-induced paw edema in mice.
  • Chenopodin treatment markedly decreased neutrophil infiltration into inflamed tissue.

Conclusions:

  • Chenopodin exhibits significant *in vivo* anti-inflammatory activity.
  • The protein effectively modulates key inflammatory responses, including edema and neutrophil recruitment.
  • Chenopodin represents a potential therapeutic agent for inflammatory conditions.