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Chenopodin as an anti-inflammatory compound
Dávia Guimarães Pompeu1, Helon Guimarães Cordeiro2, Flávia Cristina Policarpo Tonelli1
1Campus Centro-Oeste Dona Lindu, Federal University of São João Del Rei (UFSJ), Divinopolis, Minas Gerais, Brazil.
Abstract:
Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation. Chenopodin presented two subunits on its structure and has N-terminal homology with other Chenopodin in 92%. Chenopodin decreased paw edema and neutrophil recruitment induced by carrageenan in mice. Concluding, we demonstrated that Chenopodin exhibits in vivo anti-inflammatory activity.
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