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Recent Studies on Neglected Drug Design.

Natália Ferreira de Sousa1, Luciana Scotti1, Gabriela Cristina Soares Rodrigues1

  • 1Postgraduate Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraiba, Joao Pessoa-PB, Brazil.

Current Topics in Medicinal Chemistry
|September 21, 2021
PubMed
Summary

Medicinal Chemistry accelerates drug discovery for neglected diseases like Chagas disease and leishmaniasis. Computational approaches and organic synthesis are key strategies for developing new therapeutic alternatives.

Keywords:
Computer-aided drug design (CADD)Drug discoveryLigand-based drug design (LBDD)Medicinal chemistryNeglected diseasesOrganic synthesis.Structure-based drug design (SBDD)

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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Neglected Diseases

Background:

  • Neglected diseases are severe, complex health issues disproportionately affecting impoverished populations.
  • Lack of access to basic rights, including sanitation, exacerbates the impact of these diseases.
  • Medicinal Chemistry offers a vital pathway for discovering and developing new therapeutic alternatives.

Purpose of the Study:

  • To conduct a bibliographic review of recent Medicinal Chemistry studies focused on neglected diseases.
  • To identify current trends and strategies in drug design for these challenging conditions.

Main Methods:

  • A comprehensive literature search was performed using the Web of Sciences database.
  • The review focused on recent articles related to the design of drugs for neglected diseases.

Main Results:

  • Chagas disease and leishmaniasis were the most frequently studied neglected diseases.
  • Common strategies included organic synthesis, structure optimization, and the development of molecular hybrids.
  • There is a notable increase in computationally driven studies, enhancing efficiency and cost-effectiveness.

Conclusions:

  • Computer-Aided Drug Design (CADD) and organic synthesis are crucial in Medicinal Chemistry for neglected diseases.
  • These approaches aid in planning experimental methodologies and identifying high-potential active compounds.
  • The integration of CADD and synthesis accelerates the research and discovery pipeline for much-needed treatments.