Scrotal wall leiomyosarcoma: a case report and review of the literature
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Updated: Oct 19, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Zahra Erfani1, Aileen Azari-Yam2, Seyed Reza Yahyazadeh3
1Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background:
Up to 30% of all scrotal masses are sarcomas. Leiomyosarcoma of the scrotal wall is rare, and its clinical significance and prognosis have not been well defined, since the most reported cases have little or no follow-up.
Case Presentation:
We report a 45-year-old Caucasian man who was admitted with a firm, nontender, mobile scrotal wall mass from 15 months ago. Laboratory data including testicular tumor markers were within normal range, and transscrotal ultrasonography revealed an oval-shaped, hypoechogenic, solid mass with blood flow and well-defined border. Histopathologic examination and immunohistochemistry staining, following surgical excision, were in favor of malignant leiomyosarcoma.
Conclusion:
Here we describe the morphological features and immunohistochemical presentations of the tumor and the patient's relatively long-term follow-up.
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