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Significance of Glycemic Variability in Diabetes Mellitus

Yoshiki Kusunoki1, Kosuke Konishi1, Taku Tsunoda1

  • 1Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|September 21, 2021
PubMed

Insights

Strict glycemic control in diabetes can be risky. Glycemic variability (GV) is a key factor in diabetic complications, and understanding its impact is crucial for effective treatment strategies.

Area of Science:

  • Endocrinology and Metabolism
  • Diabetes Research
  • Clinical Medicine

Background:

  • Diabetes treatment aims for glycemic control, preventing complications, and ensuring quality of life.
  • Hemoglobin A1c (HbA1c) is a standard glycemic control index, but strict control can cause severe hypoglycemia and cardiovascular events.
  • Emerging evidence highlights glycemic variability (GV) as a critical factor in diabetic complications.

Purpose of the Study:

  • To review the definition and clinical utility of glycemic variability (GV).
  • To evaluate the association between GV and diabetic complications.
  • To explore therapeutic strategies for reducing GV in diabetes management.

Main Methods:

  • Literature review on glycemic variability.
  • Analysis of studies correlating GV with diabetic vascular complications.
  • Examination of treatment approaches targeting GV reduction.

Main Results:

  • Glycemic variability, encompassing hyperglycemia and hypoglycemia, is linked to diabetic vascular complications.
  • GV is recognized as an important index for assessing glycemic control effectiveness.
  • Specific therapeutic strategies can effectively reduce GV.

Conclusions:

  • Glycemic variability is a significant factor in diabetes management, impacting complication development.
  • Monitoring and managing GV alongside HbA1c offers a more comprehensive approach to glycemic control.
  • Targeting GV reduction is a promising strategy for improving outcomes in diabetic patients.

Keywords:
continuous glucose monitoringdiabetic macrovascular complicationsdiabetic microvascular complicationsglycemic variabilitytime in range

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