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Updated: Oct 19, 2025

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
Published on: October 30, 2014
Making transport more robust and interpretable by moving data through a small number of anchor points
Chi-Heng Lin1, Mehdi Azabou1,2, Eva L Dyer1,2,3
1Department of Electrical and Computer Engineering, Georgia Tech, Atlanta, Georgia, USA.
Abstract:
Optimal transport (OT) is a widely used technique for distribution alignment, with applications throughout the machine learning, graphics, and vision communities. Without any additional structural assumptions on transport, however, OT can be fragile to outliers or noise, especially in high dimensions. Here, we introduce Latent Optimal Transport (LOT), a new approach for OT that simultaneously learns low-dimensional structure in data while leveraging this structure to solve the alignment task. The idea behind our approach is to learn two sets of "anchors" that constrain the flow of transport between a source and target distribution. In both theoretical and empirical studies, we show that LOT regularizes the rank of transport and makes it more robust to outliers and the sampling density. We show that by allowing the source and target to have different anchors, and using LOT to align the latent spaces between anchors, the resulting transport plan has better structural interpretability and highlights connections between both the individual data points and the local geometry of the datasets.
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