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Updated: Oct 19, 2025

Pan-lyssavirus Real Time RT-PCR for Rabies Diagnosis
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Seoul Virus Associated with Pet Rats, Scotland, UK, 2019.

James G Shepherd, Andrew E Blunsum, Stephen Carmichael

    Emerging Infectious Diseases
    |September 21, 2021
    PubMed
    Summary

    A case of hemorrhagic fever with renal syndrome caused by Seoul virus was identified in Scotland. Genetic analysis revealed the virus is part of a rapidly expanding lineage, likely linked to the international pet rat trade.

    Keywords:
    SEOVScotlandSeoul hantavirusSeoul virusUnited Kingdomhantavirushantavirus infectionshemorrhagic fever with renal syndromepetsratsviral zoonosesviruseswhole-genome sequencing

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    Area of Science:

    • Infectious Diseases
    • Virology
    • Genomics

    Background:

    • Hemorrhagic fever with renal syndrome (HFRS) is a group of zoonotic diseases caused by hantaviruses.
    • Seoul virus, a species of hantavirus, is known to infect rodents, particularly brown and black rats, and can be transmitted to humans.

    Observation:

    • A case of HFRS was diagnosed in a woman in Scotland, UK.
    • The patient's infection was caused by Seoul virus.

    Findings:

    • Whole-genome sequencing of the Seoul virus isolate revealed it belongs to a lineage exhibiting recent international expansion.
    • This expansion is strongly suspected to be driven by the global trade of pet rats.

    Implications:

    • This case highlights the potential for Seoul virus to emerge in new geographic regions, including the UK.
    • The findings underscore the importance of monitoring the pet trade for zoonotic disease risks.
    • Further research into hantavirus surveillance and control measures in the context of international pet trafficking is warranted.