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Effectiveness of Ozone Therapy as an Adjunct Treatment for Lower-Limb Ulcers: A Systematic Review
Tássia Lima Bomfim1, Isla Alcântara Gomes, Daniele de Vasconcelos Cerqueira Meneses
1At the Fundação Universidade Federal de Sergipe, São Cristóvão, Brazil, Tássia Lima Bomfim, MSc, is Nurse, Wound Healing Outpatient Clinic, University Hospital; Isla Alcântara Gomes, MSc, is PhD Student, Pharmaceutical Sciences; Daniele de Vasconcelos Cerqueira Meneses, MSc, is Master's Student, Health Sciences; and Adriano Antunes de Souza Araujo, PhD, is Director, Center of Biological and Health Sciences. Acknowledgments: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil and Fundação de Amparo à Pesquisa do Estado de Sergipe/FAPITEC-SE for their financial support. The authors have disclosed no other financial relationships related to this article. Submitted March 22, 2021; accepted in revised form May 10, 2021.
Objective:
To evaluate the effectiveness of topical ozone therapy as an adjuvant treatment in the healing of lower limb ulcers through a systematic literature review.
Data Sources:
Three databases were used to search for studies conducted in the period up to and including September 2020: PubMed, Scopus, and the Web of Science.
Study Selection:
The search identified 44 studies, 7 of which met the eligibility criteria and were evaluated.
Data Extraction:
Study design, study location, number of patients, patient age, type of control, wound type, intervention type, equipment used to generate ozone (ozone generation), evaluation methodology, and main results were extracted from each study.
Data Synthesis:
A total of 506 patients 18 years or older with chronic wounds, such as venous or diabetic ulcers, on the lower limbs were enrolled. The majority of studies addressed diabetic foot ulcers.
Conclusions:
The ozone therapy protocols demonstrated a healing effect in all included studies, and none reported adverse effects. This reinforces the need for more controlled and randomized clinical trials to determine the effectiveness of this treatment and establish clinical criteria for its use.
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