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Updated: Oct 19, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sleep Endoscopy Patterns in Six Adults With Trisomy 21 and Obstructive Sleep Apnea
Lee Porterfield1, Bartholomew Bacak1, Sveta Karelsky1
1Department of Otolaryngology Rochester, University of Rochester Medical Center, NY, USA.
Abstract:
Obstructive sleep apnea (OSA) is prevalent amongst individuals with Trisomy 21 (T21). This case series describes the results of drug-induced sleep endoscopy of six adult patients with OSA and T21 and compares the patterns of collapse to those observed in adults without T21. Predominantly hypopharyngeal airway collapse was found in four of the six (66.7%) subjects with T21, a much higher proportion than in the general population. This finding may implicate anatomic differences underlying the increased prevalence of OSA in individuals with T21 and may have treatment implications. Laryngoscope, 132:485-487, 2022.
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