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Kidney Transplant Cortical Necrosis Observed During Pelvic Radiation Therapy
Arunima Jain1, Apsara Windsor2, Angela Chou3
1Department of Renal Medicine, Gosford Hospital, Gosford, New South Wales, Australia.
Practical Radiation Oncology
|September 21, 2021
Summary
A kidney transplant recipient experienced severe kidney damage during cancer treatment. This case highlights potential risks of chemoradiation therapy in transplant patients, requiring further investigation.
Area of Science:
- Nephrology
- Oncology
- Transplant Surgery
Background:
- Concurrent chemoradiation therapy is a standard treatment for advanced anal squamous cell carcinoma.
- Kidney transplant recipients often have unique physiological considerations during cancer treatment.
Observation:
- A 61-year-old female kidney transplant recipient underwent concurrent chemoradiation for anal squamous cell carcinoma.
- The patient developed elevated serum creatinine levels, indicating kidney dysfunction.
Findings:
- Radiologic and biopsy-confirmed cortical necrosis of the transplanted kidney occurred during therapy.
- This represents the first documented instance of acute anatomic and pathologic changes in a transplanted kidney during chemoradiation.
Implications:
- Chemoradiation therapy may pose significant risks to transplanted kidneys.
- Further research is needed to understand the long-term consequences and develop management strategies for transplant recipients undergoing such treatments.
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