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Updated: Oct 19, 2025

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
Published on: August 26, 2011
Emotion regulation ability compensates for the depression-related negativity bias
Rainer Düsing1, Elise L Radtke1, Julius Kuhl1
1Osnabrück University, Germany.
Abstract:
Emotion regulation ability (ERA) enables individuals to disengage from negative stimuli. In this study, we investigated the role of ERA in the depression-related negativity bias. Seventy-four individuals with major depressive disorder and eighty-three nonclinical individuals were screened for depressiveness using the Beck Depression Inventory. ERA was assessed using the Action Orientation After Failure Subscale of the Action Control Scale. We used a classical Stroop task variant, wherein the color words were preceded by either a self-relevant positive (success-related), negative (failure-related), or neutral word prime. The expected depressiveness × emotional prime interaction did not reach significance but the expected ERA × emotional prime interaction did. The latter effect was qualified by a three-way interaction between ERA, depressiveness, and emotional prime. Specifically, ERA predicted the negativity bias in individuals with high depressiveness scores. Using the Johnson-Neyman technique, we found that this effect was significant at the level of mild to moderate depression and beyond. Thus, poor ERA in individuals with depression may cause the depression-related negativity bias, whereas (at least) moderate ERA may protect individuals with depression from this bias. Future studies should assess ERA in individuals with depressive symptomatology and investigate how it influences their everyday functioning and treatment outcomes.
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